Drug Discovery & Development
We identify, synthesize, and test novel pharmaceutical compounds with potent anti-inflammatory properties. Our research focuses on creating safer, more effective treatments for inflammatory conditions.
Clinical Research Support
We partner with leading medical institutions to advance our discoveries from laboratory to clinical applications, supporting groundbreaking studies like the COVID-19 NAG treatment research.
Preclinical Research
Our laboratory conducts comprehensive preclinical studies including: – Cell viability and cytotoxicity assessments – Anti-inflammatory efficacy testing – Molecular mechanism analysis – Safety profiling and dose optimization
Pharmaceutical Innovation
Through systematic compound screening and optimization, we develop next-generation therapeutics that offer improved efficacy with reduced side effects compared to existing treatments.
Current Treatment Limitations:
Existing anti-inflammatory drugs often lead to serious side effects and frequently provide only partial symptom relief. Options are limited for patients who don’t respond to standard therapies, highlighting a growing need for safer and more targeted interventions.
Improving Patient Outcomes
Every compound we develop is designed with the patient in mind. Our goal is to reduce suffering from inflammatory conditions, provide safer treatment alternatives, offer hope to those with limited options, and advance the field of anti-inflammatory medicine.
Scientific Excellence
We maintain the highest standards of research integrity, ensuring our discoveries are backed by robust scientific evidence and rigorous testing protocols.
Transforming Treatment Landscapes
Our goal is to fundamentally change how inflammatory diseases are treated, moving from symptom management to targeted, effective interventions that improve quality of life without compromising safety.
Breakthrough Research in Pandemic Response
Our N-acetyl glucosamine (NAG) research has shown remarkable promise in COVID-19 treatment: 50% reduction in ICU admissions, Significantly shortened hospital stays, More than 50% reduction in mortality rates, and Well-tolerated with minimal side effects
Ongoing Investigation:
Expanding research into other viral infections where inflammatory response plays a critical role in disease severity.
Targeting Overactive Immune Responses
Our compounds show potential for treating conditions where the immune system attacks healthy tissue: Rheumatoid arthritis, Inflammatory bowel disease, Multiple sclerosis-related inflammation, and Systemic lupus erythematosus.
Beyond Traditional Pain Management
Developing treatments for pain conditions with inflammatory components: Osteoarthritis, Chronic inflammatory pain, Post-surgical inflammation, and Sports-related inflammatory injuries.
Addressing Lung and Airway Inflammation
Research focuses on conditions affecting respiratory health: Asthma and allergic responses, Chronic obstructive pulmonary disease (COPD), Acute respiratory distress syndrome, and Pneumonia-related inflammation.
Expanding Our Impact
Based on our research findings, we’re exploring applications in: Cardiovascular inflammatory conditions, Neuroinflammatory diseases, Metabolic inflammatory disorders, and Cancer-related inflammation.
NDX1 (AB25213) – Primary Anti-Inflammatory Agent
Our flagship compound demonstrating superior anti-inflammatory activity.
Key Properties:
This compound shows the highest inhibition of inflammatory response among those tested. It effectively reduces IL-6 and TNF-α levels and strongly inhibits iNOS and IL-1β mRNA expression. Its anti-inflammatory effects are dose-dependent.
Research Findings:
It is the most effective at reducing cytokine production and demonstrates superior inhibition of nitric oxide. Efficacy has also been confirmed in macrophage activation models.
NDX2 – Secondary Development Compound
A related molecule with distinct anti-inflammatory properties.
Characteristics:
This compound has a lower cytotoxicity profile than NDX1 and exhibits moderate anti-inflammatory activity. It works through a different mechanism of action and shows promise for use in combination therapies.
Development Status:
Currently undergoing optimization for improved efficacy and reduced toxicity.
N-Acetyl Glucosamine (NAG) – Clinical Validation
While not invented by us, we’ve pioneered its clinical application in COVID-19 treatment.
Our Contribution:
We conducted the first clinical investigation of NAG for COVID-19. This included dosage optimization at 700mg twice daily, validation of safety and efficacy, and development of the clinical protocol.
Proven Results:
A 48-patient clinical study validated the approach, showing significant improvement in patient outcomes. The treatment has an established safety profile and is ready for larger clinical trials.
Multi-Target Approach
We’ve investigated combination strategies to enhance therapeutic effects:
We explored combinations of NDX1 with vitamin C and folate, leading to the development of synergistic compounds and optimized dosing regimens to enhance therapeutic effects.
Future Molecular Development
Our pipeline includes:
Our pipeline features next-generation NDX compounds, targeted delivery systems, and precision medicine strategies, including biomarker-guided therapeutics.
Advanced Anti-Inflammatory Research Platform
Partner with us to access cutting-edge anti-inflammatory research capabilities and validated research protocols.
Ready to Collaborate?
Contact our research team to discuss how we can support your anti-inflammatory research objectives and advance scientific discovery together.
Revolutionary Anti-Inflammatory Drug Development
Theraputikos represents a unique investment opportunity in the rapidly growing anti-inflammatory therapeutics market, with validated compounds and proven clinical results.
Massive Market Potential
The global anti-inflammatory drugs market exceeds $100 billion annually. Demand is growing for safer therapeutic alternatives, driven by unmet medical needs in inflammatory diseases. An aging population is also contributing to the market’s continued expansion.
COVID-19 Treatment Market
There is an ongoing need for effective COVID-19 treatments. Opportunities also exist in addressing post-acute COVID syndrome. These efforts support pandemic preparedness and benefit from available government and institutional funding.
Validated Clinical Results
A first-in-class NAG clinical study has shown proven efficacy, with a 50% reduction in ICU admissions and a significant decrease in mortality. The treatment also has a strong safety profile, supporting its potential impact.
Proprietary Compound Portfolio
NDX1 demonstrates superior anti-inflammatory activity. The pipeline includes multiple development-stage compounds. Strong intellectual property protection and scalable synthesis processes support future growth and commercialization.
We welcome discussions with investors who share our vision of transforming inflammatory disease treatment through innovative drug discovery.
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